| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CLIC1/NCC27 (45-57) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CLIC1 |
| Gene ID: |
1192 |
| Uniprot ID: |
CLIC1_HUMAN |
| Immunogen Region: |
45-57 |
| Accession Number: |
NP_001279.2 |
| Immunogen Sequence: |
TVDTKRRTETVQK |
| Post Translational Modifications | Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. |
| Function | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. |
| Protein Name | Chloride Intracellular Channel Protein 1Chloride Channel AbpNuclear Chloride Ion Channel 27Ncc27Regulatory Nuclear Chloride Ion Channel ProteinHrncc |
| Cellular Localisation | NucleusNucleus MembraneSingle-Pass Membrane ProteinCytoplasmCell MembraneEndoplasmic ReticulumMostly In The Nucleus Including In The Nuclear MembraneSmall Amount In The Cytoplasm And The Plasma MembraneExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 1 antibodyAnti-Chloride Channel Abp antibodyAnti-Nuclear Chloride Ion Channel 27 antibodyAnti-Ncc27 antibodyAnti-Regulatory Nuclear Chloride Ion Channel Protein antibodyAnti-Hrncc antibodyAnti-CLIC1 antibodyAnti-G6 antibodyAnti-NCC27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation analysis of 300 Mu g extracts of Hela cells using 3 Mu g [KD Validated] CLIC1 Rabbit polyclonal antibody (STJ11105200). Western blot was performed from the immunoprecipitate using [KO Validated] CLIC1 Rabbit polyclonal antibody (STJ11105200) at a dilition of 1:2000.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177844/369805/STJ11105200_1__23729.1713135378.jpg?c=1 "Immunoprecipitation analysis of 300 Mu g extracts of Hela cells using 3 Mu g [KD Validated] CLIC1 Rabbit polyclonal antibody (STJ11105200). Western blot was performed from the immunoprecipitate using [KO Validated] CLIC1 Rabbit polyclonal antibody (STJ11105200) at a dilition of 1:2000.")