| Tissue Specificity | Expression is prominent in heart, placenta, liver, kidney and pancreas. |
| Post Translational Modifications | Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. |
| Protein Name | Chloride Intracellular Channel Protein 1Chloride Channel AbpGlutaredoxin-Like Oxidoreductase Clic1Glutathione-Dependent Dehydroascorbate Reductase Clic1Nuclear Chloride Ion Channel 27Ncc27Regulatory Nuclear Chloride Ion Channel ProteinHrncc |
| Database Links | |
| Cellular Localisation | NucleusNucleus MembraneSingle-Pass Membrane ProteinCytoplasmCell MembraneEndoplasmic ReticulumMostly In The Nucleus Including In The Nuclear MembraneSmall Amount In The Cytoplasm And The Plasma MembraneExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 1 antibodyAnti-Chloride Channel Abp antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic1 antibodyAnti-Glutathione-Dependent Dehydroascorbate Reductase Clic1 antibodyAnti-Nuclear Chloride Ion Channel 27 antibodyAnti-Ncc27 antibodyAnti-Regulatory Nuclear Chloride Ion Channel Protein antibodyAnti-Hrncc antibodyAnti-CLIC1 antibodyAnti-G6 antibodyAnti-NCC27 antibody |
Information sourced from Uniprot.org
