Anti-CLIC1 antibody (166-216 aa) (STJ197407)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide derived from CLIC1 at the amino acid range 166-216
General Information
| Short Description | Rabbit polyclonal anti-Chloride intracellular channel protein 1 (166-216 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLIC1 |
| Gene ID | 1192 |
| Uniprot ID | CLIC1_HUMAN |
| Immunogen | Synthetic peptide derived from CLIC1 at the amino acid range 166-216 |
| Immunogen Region | 166-216 aa |
| Specificity | CLIC1 protein (A216) detects endogenous levels of CLIC1 |
Additional Info
| Post Translational Modifications | Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. |
| Protein Name | Chloride Intracellular Channel Protein 1Chloride Channel AbpGlutaredoxin-Like Oxidoreductase Clic1Glutathione-Dependent Dehydroascorbate Reductase Clic1Nuclear Chloride Ion Channel 27Ncc27Regulatory Nuclear Chloride Ion Channel ProteinHrncc |
| Database Links | |
| Cellular Localisation | NucleusNucleus MembraneSingle-Pass Membrane ProteinCytoplasmCell MembraneEndoplasmic ReticulumMostly In The Nucleus Including In The Nuclear MembraneSmall Amount In The Cytoplasm And The Plasma MembraneExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 1 antibodyAnti-Chloride Channel Abp antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic1 antibodyAnti-Glutathione-Dependent Dehydroascorbate Reductase Clic1 antibodyAnti-Nuclear Chloride Ion Channel 27 antibodyAnti-Ncc27 antibodyAnti-Regulatory Nuclear Chloride Ion Channel Protein antibodyAnti-Hrncc antibodyAnti-CLIC1 antibodyAnti-G6 antibodyAnti-NCC27 antibody |
Information sourced from Uniprot.org