• Immunohistochemical analysis of paraffin-embedded Human Colon Tissue using CLIC1Rabbit pAb diluted at 1:200.
  • Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using CLIC1Rabbit pAb diluted at 1:200.

Anti-CLIC1 antibody (166-216 aa) (STJ197407)

SKU:
STJ197407

Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chloride intracellular channel protein 1 (166-216 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLIC1
Gene ID: 1192
Uniprot ID: CLIC1_HUMAN
Immunogen Region: 166-216 aa
Specificity: CLIC1 protein (A216) detects endogenous levels of CLIC1
Immunogen: Synthetic peptide derived from CLIC1 at the amino acid range 166-216
Post Translational Modifications Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
Function Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Protein Name Chloride Intracellular Channel Protein 1
Chloride Channel Abp
Nuclear Chloride Ion Channel 27
Ncc27
Regulatory Nuclear Chloride Ion Channel Protein
Hrncc
Cellular Localisation Nucleus
Nucleus Membrane
Single-Pass Membrane Protein
Cytoplasm
Cell Membrane
Endoplasmic Reticulum
Mostly In The Nucleus Including In The Nuclear Membrane
Small Amount In The Cytoplasm And The Plasma Membrane
Exists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain
Might Not Be Present In The Nucleus Of Cardiac Cells
Alternative Antibody Names Anti-Chloride Intracellular Channel Protein 1 antibody
Anti-Chloride Channel Abp antibody
Anti-Nuclear Chloride Ion Channel 27 antibody
Anti-Ncc27 antibody
Anti-Regulatory Nuclear Chloride Ion Channel Protein antibody
Anti-Hrncc antibody
Anti-CLIC1 antibody
Anti-G6 antibody
Anti-NCC27 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance