Anti-CLEC5A antibody (29-188) (STJ23169)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLEC5A (29-188) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC5A |
| Gene ID | 23601 |
| Uniprot ID | CLC5A_HUMAN |
| Immunogen Region | 29-188 |
| Immunogen Sequence | QIFNKSNDGFTTTRSYGTVS QIFGSSSPSPNGFITTRSYG TVCPKDWEFYQARCFFLSTS ESSWNESRDFCKGKGSTLAI VNTPEKLKFLQDITDAEKYF IGLIYHREEKRWRWINNSVF NGNVTNQNQNFNCATIGLTK TFDAASCDISYRRICEKNAK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 29-188 of human CLEC5A (NP_037384.1). |
Additional Info
| Tissue Specificity | Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release. |
| Protein Name | C-Type Lectin Domain Family 5 Member AC-Type Lectin Superfamily Member 5Myeloid Dap12-Associating Lectin 1Mdl-1 |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 5 Member A antibodyAnti-C-Type Lectin Superfamily Member 5 antibodyAnti-Myeloid Dap12-Associating Lectin 1 antibodyAnti-Mdl-1 antibodyAnti-CLEC5A antibodyAnti-CLECSF5 antibodyAnti-MDL1 antibody |
Information sourced from Uniprot.org