| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC4M (71-399) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC4M |
| Gene ID: |
10332 |
| Uniprot ID: |
CLC4M_HUMAN |
| Immunogen Region: |
71-399 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 71-399 of human CLEC4M (NP_055072.3). |
| Immunogen Sequence: |
QVSKVPSSLSQEQSEQDAIY QNLTQLKAAVGELSEKSKLQ EIYQELTQLKAAVGELPEKS KLQEIYQELTRLKAAVGELP EKSKLQEIYQELTRLKAAVG ELPEKSKLQEIYQELTRLKA AVGELPEKSKLQEIYQELTE LKAAVGELPEKSKLQEIYQE LTQLKAAVGELPDQSKQQQI YQELTDLKTAFERLCRHCPK DWTFFQGNCYFMSNSQRNWH DSVTACQEVRAQLVVIKTA |
| Tissue Specificity | Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. |
| Function | Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS-CoV. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. |
| Protein Name | C-Type Lectin Domain Family 4 Member MCd209 Antigen-Like Protein 1Dc-Sign-Related ProteinDc-SignrDendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2Dc-Sign2Liver/Lymph Node-Specific Icam-3-Grabbing Non-IntegrinL-SignCd Antigen Cd299 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 5: SecretedIsoform 6: SecretedIsoform 7: SecretedIsoform 10: Secreted |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member M antibodyAnti-Cd209 Antigen-Like Protein 1 antibodyAnti-Dc-Sign-Related Protein antibodyAnti-Dc-Signr antibodyAnti-Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2 antibodyAnti-Dc-Sign2 antibodyAnti-Liver/Lymph Node-Specific Icam-3-Grabbing Non-Integrin antibodyAnti-L-Sign antibodyAnti-Cd Antigen Cd299 antibodyAnti-CLEC4M antibodyAnti-CD209L antibodyAnti-CD209L1 antibodyAnti-CD299 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
