| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC4E (120-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC4E |
| Gene ID: |
26253 |
| Uniprot ID: |
CLC4E_HUMAN |
| Immunogen Region: |
120-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human CLEC4E (NP_055173.1). |
| Immunogen Sequence: |
SQEEQEFLSYKKPKMREFFI GLSDQVVEGQWQWVDGTPLT KSLSFWDVGEPNNIATLEDC ATMRDSSNPRQNWNDVTCFL N |
| Tissue Specificity | Expressed in monocytes and macrophages. |
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. |
| Protein Name | C-Type Lectin Domain Family 4 Member EC-Type Lectin Superfamily Member 9Macrophage-Inducible C-Type LectinMincle |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCell ProjectionPhagocytic Cup |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member E antibodyAnti-C-Type Lectin Superfamily Member 9 antibodyAnti-Macrophage-Inducible C-Type Lectin antibodyAnti-Mincle antibodyAnti-CLEC4E antibodyAnti-CLECSF9 antibodyAnti-MINCLE antibodyAnti-UNQ218 antibodyAnti-PRO244 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
