Anti-Cleaved-KLKB1-R390 antibody (341-390 aa) (STJ90101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KLKB1 at the amino acid range 341-390
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Plasma kallikrein-R390 (341-390 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLKB1 |
| Gene ID | 3818 |
| Uniprot ID | KLKB1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KLKB1 at the amino acid range 341-390 |
| Immunogen Region | 341-390 aa |
| Specificity | Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody detects endogenous levels of fragment of activated Plasma Kallikrein HC protein resulting from cleavage adjacent to R390. |
Additional Info
| Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| Protein Name | Plasma KallikreinFletcher FactorKininogeninPlasma PrekallikreinPkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-1592389Reactome: R-HSA-9657688Reactome: R-HSA-9657689 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Kallikrein antibodyAnti-Fletcher Factor antibodyAnti-Kininogenin antibodyAnti-Plasma Prekallikrein antibodyAnti-Pkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain antibodyAnti-KLKB1 antibodyAnti-KLK3 antibody |
Information sourced from Uniprot.org