• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-ITGA8-Arg906, Heavy Chain antibody (906-907) (STJA0005874)

SKU:
STJA0005874

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Integrin alpha-8-Arg906, Heavy Chain (906-907) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITGA8
Gene ID: 8516
Uniprot ID: ITA8_HUMAN
Immunogen Region: 906-907
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat ITGA8 (heavy chain, Cleaved-Arg906, protein was cleaved amino acid sequence between 906-907 )
Immunogen: Synthesized peptide derived from human ITGA8 (heavy chain, Cleaved-Arg906)
Tissue Specificity Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Function Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Protein Name Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain
Database Links Reactome: R-HSA-2129379
Reactome: R-HSA-216083
Reactome: R-HSA-2173789
Reactome: R-HSA-3000178
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Alternative Antibody Names Anti-Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain antibody
Anti-ITGA8 antibody

Information sourced from Uniprot.org

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