| Post Translational Modifications | Cleaved by autocatalysis into a large and a small subunit. Glycosylated. |
| Function | Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4. Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine. May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses. |
| Protein Name | Glutathione Hydrolase 5 ProenzymeGamma-Glutamyl Transpeptidase-Related EnzymeGgt-RelGamma-Glutamyltransferase 5Ggt 5Gamma-Glutamyltransferase-Like Activity 1Gamma-Glutamyltranspeptidase 5Leukotriene-C4 Hydrolase Cleaved Into - Glutathione Hydrolase 5 Heavy Chain - Glutathione Hydrolase 5 Light Chain |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-2142691Reactome: R-HSA-5423646Reactome: R-HSA-9664535Reactome: R-HSA-9753281 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Glutathione Hydrolase 5 Proenzyme antibodyAnti-Gamma-Glutamyl Transpeptidase-Related Enzyme antibodyAnti-Ggt-Rel antibodyAnti-Gamma-Glutamyltransferase 5 antibodyAnti-Ggt 5 antibodyAnti-Gamma-Glutamyltransferase-Like Activity 1 antibodyAnti-Gamma-Glutamyltranspeptidase 5 antibodyAnti-Leukotriene-C4 Hydrolase Cleaved Into - Glutathione Hydrolase 5 Heavy Chain - Glutathione Hydrolase 5 Light Chain antibodyAnti-GGT5 antibodyAnti-GGTLA1 antibody |
Information sourced from Uniprot.org
