| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Cleaved-Coagulation factor VIII-Arg759, Heavy Chain (759-760) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F8 |
| Gene ID: | 2157 |
| Uniprot ID: | FA8_HUMAN |
| Immunogen Region: | 759-760 |
| Specificity: | This antibody detects endogenous levels of Human, Mouse FA8A (heavy chain 92k, Cleaved-Arg759, protein was cleaved amino acid sequence between 759-760 ) |
| Immunogen: | Synthesized peptide derived from human FA8A (heavy chain 92k, Cleaved-Arg759) |
| Post Translational Modifications | Sulfation on Tyr-1699 is essential for binding vWF. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form. |
| Function | Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
| Protein Name | Coagulation Factor ViiiAntihemophilic FactorAhfProcoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-163841Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-9672383Reactome: R-HSA-9672387Reactome: R-HSA-9672391Reactome: R-HSA-9672393Reactome: R-HSA-9672395Reactome: R-HSA-9672396Reactome: R-HSA-9672397Reactome: R-HSA-9673202Reactome: R-HSA-9674519 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Coagulation Factor Viii antibodyAnti-Antihemophilic Factor antibodyAnti-Ahf antibodyAnti-Procoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain antibodyAnti-F8 antibodyAnti-F8C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance