Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XI-Glu19, Heavy Chain (18-19) is suitable for use in Western Blot and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
F11 |
Gene ID: |
2160 |
Uniprot ID: |
FA11_HUMAN |
Immunogen Region: |
18-19 |
Specificity: |
This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Glu19, protein was cleaved amino acid sequence between 18-19 ) |
Immunogen: |
Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Glu19) |
Tissue Specificity | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
Post Translational Modifications | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. |
Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
Protein Name | Coagulation Factor XiFxiPlasma Thromboplastin AntecedentPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain |
Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9673221 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Coagulation Factor Xi antibodyAnti-Fxi antibodyAnti-Plasma Thromboplastin Antecedent antibodyAnti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibodyAnti-F11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance