| Tissue Specificity | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
| Post Translational Modifications | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated).the presence of negatively charged surfaces accelerates activation. Activated by F2 (thrombin).the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation. Autoactivated.the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis. |
| Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
| Protein Name | Coagulation Factor XiFxiPlasma Thromboplastin AntecedentPta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-9673221 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coagulation Factor Xi antibodyAnti-Fxi antibodyAnti-Plasma Thromboplastin Antecedent antibodyAnti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibodyAnti-F11 antibody |
Information sourced from Uniprot.org
