| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Cathepsin K-Ala115 (114-115) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CTSK |
| Gene ID: |
1513 |
| Uniprot ID: |
CATK_HUMAN |
| Immunogen Region: |
114-115 |
| Specificity: |
This antibody detects endogenous levels of Human, Mouse, Rat CATK (Cleaved-Ala115, protein was cleaved amino acid sequence between 114-115 ) |
| Immunogen: |
Synthesized peptide derived from human CATK (Cleaved-Ala115) |
| Tissue Specificity | Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells. |
| Function | Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. |
| Protein Name | Cathepsin KCathepsin OCathepsin O2Cathepsin X |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-1679131Reactome: R-HSA-2132295Reactome: R-HSA-8939242 |
| Cellular Localisation | LysosomeSecretedApical Cell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells |
| Alternative Antibody Names | Anti-Cathepsin K antibodyAnti-Cathepsin O antibodyAnti-Cathepsin O2 antibodyAnti-Cathepsin X antibodyAnti-CTSK antibodyAnti-CTSO antibodyAnti-CTSO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
