| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Claudin-8 (81-130 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN8 |
| Gene ID: |
9073 |
| Uniprot ID: |
CLD8_HUMAN |
| Immunogen Region: |
81-130 aa |
| Specificity: |
Claudin-8 Polyclonal Antibody detects endogenous levels of Claudin-8 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CLDN8 at the amino acid range 81-130 |
| Post Translational Modifications | Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-8 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinLocalizes To Tight Junctions In All 3 Segments Of The EpididymisIn The Caput Found In The Lateral Margins Of Principal CellsAnd In The Corpus At The Interface Between Basal And Principal Cells |
| Alternative Antibody Names | Anti-Claudin-8 antibodyAnti-CLDN8 antibodyAnti-UNQ779 antibodyAnti-PRO1573 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
