| Host: | Mouse |
| Applications: | IHC/IF/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Claudin-4 (150-209 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-CLD4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500WB 1:500-2000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLDN4 |
| Gene ID: | 1364 |
| Uniprot ID: | CLD4_HUMAN |
| Immunogen Region: | 150-209 aa |
| Specificity: | This antibody detects endogenous levels of human Claudin 4. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section. The antibody w |
| Immunogen: | Synthesized peptide derived from the human Claudin 4 at the amino acid range 150-209 |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-4Clostridium Perfringens Enterotoxin ReceptorCpe-RCpe-ReceptorWilliams-Beuren Syndrome Chromosomal Region 8 Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-4 antibodyAnti-Clostridium Perfringens Enterotoxin Receptor antibodyAnti-Cpe-R antibodyAnti-Cpe-Receptor antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 8 Protein antibodyAnti-CLDN4 antibodyAnti-CPER antibodyAnti-CPETR1 antibodyAnti-WBSCR8 antibody |
Information sourced from Uniprot.org