Anti-CLDN18 antibody [ABT185R] (STJ197061)

SKU:
STJ197061

£168.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Claudin-18 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Clone ID: ABT185R
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-1:200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLDN18
Gene ID: 51208
Uniprot ID: CLD18_HUMAN
Specificity: This antibody detects endogenous levels of Claudin 18 at Human
Immunogen: Synthesized peptide derived from the human Claudin 18
Function Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways. Isoform A1: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C. neoformans infection. Isoform A2: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification.
Protein Name Claudin-18
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Localizes To Tight Junctions In Epithelial Cells
Isoform A1: Cell Junction
Isoform A2: Cell Junction
Lateral Cell Membrane
Alternative Antibody Names Anti-Claudin-18 antibody
Anti-CLDN18 antibody
Anti-UNQ778 antibody
Anti-PRO1572 antibody

Information sourced from Uniprot.org

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