| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLDN17 |
| Gene ID: | 26285 |
| Uniprot ID: | CLD17_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_036263.1). |
| Immunogen Sequence: | CGMKQVQCTGSNERAKAYLL GTSGVLFILTGIFVLIPVSW TANIIIRDFYNPAIHIGQKR ELGAALFLGWASAAVLFIGG GLLCGFCCCNRKKQGYRYPV PGYRVPHTDKRRNTTMLSKT STSYV |
| Tissue Specificity | In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level). |
| Function | Channel-forming tight junction protein with selectivity for anions, including chloride and hydrogencarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in paracellular reabsorption of filtered anions. Does not affect water permeability. |
| Protein Name | Claudin-17 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionBasolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-17 antibodyAnti-CLDN17 antibodyAnti-UNQ758 antibodyAnti-PRO1489 antibody |
Information sourced from Uniprot.org