• Immunohistochemistry analysis of CLDN17 in paraffin-embedded mouse kidney using CLDN17 Rabbit polyclonal antibody (STJ117345) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using CLDN17 Rabbit polyclonal antibody (STJ117345) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.

Anti-CLDN17 antibody (C-Term) (STJ117345)

SKU:
STJ117345

£112.50 - £524.50
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLDN17
Gene ID: 26285
Uniprot ID: CLD17_HUMAN
Immunogen Region: C-Term
Specificity: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_036263.1).
Immunogen Sequence: CGMKQVQCTGSNERAKAYLL GTSGVLFILTGIFVLIPVSW TANIIIRDFYNPAIHIGQKR ELGAALFLGWASAAVLFIGG GLLCGFCCCNRKKQGYRYPV PGYRVPHTDKRRNTTMLSKT STSYV
Tissue Specificity In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
Function Channel-forming tight junction protein with selectivity for anions, including chloride and hydrogencarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in paracellular reabsorption of filtered anions. Does not affect water permeability.
Protein Name Claudin-17
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Basolateral Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Claudin-17 antibody
Anti-CLDN17 antibody
Anti-UNQ758 antibody
Anti-PRO1489 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance