| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN6 (1-80) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN6 |
| Gene ID: |
1185 |
| Uniprot ID: |
CLCN6_HUMAN |
| Immunogen Region: |
1-80 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CLCN6 (NP_001277.1). |
| Immunogen Sequence: |
MAGCRGSLCCCCRWCCCCGE RETRTPEELTILGETQEEED EILPRKDYESLDYDRCINDP YLEVLETMDNKKGRRYEAVK |
| Tissue Specificity | Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. |
| Post Translational Modifications | N-glycosylated on several asparagine residues. |
| Function | Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 6Chloride Channel Protein 6Clc-6Chloride Transport Protein 6 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-6802952 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 6 antibodyAnti-Chloride Channel Protein 6 antibodyAnti-Clc-6 antibodyAnti-Chloride Transport Protein 6 antibodyAnti-CLCN6 antibodyAnti-KIAA0046 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
