Anti-CLCN3 antibody (Cytoplasmic Domain) (STJ13100868)

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STJ13100868-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-CLCN3 (Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: CLCN3
Gene ID: 1182
Uniprot ID: CLCN3_HUMAN
Immunogen Region: Cytoplasmic Domain
Specificity: Specific for CLCN3.
Immunogen: A synthetic peptide from the cytoplasmic domain of rat Chloride channel protein 3 (CLCN3) conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications N-glycosylated.
Function Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
Protein Name H(+/Cl(- Exchange Transporter 3
Chloride Channel Protein 3
Clc-3
Chloride Transporter Clc-3
Database Links Reactome: R-HSA-2672351
Cellular Localisation Isoform 1: Early Endosome Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Lysosome Membrane
Cell Membrane
Isoform 1 Is Localized Mainly In Late Endosomes
Isoform 2: Golgi Apparatus Membrane
Cell Projection
Ruffle Membrane
Isoform 2 Is Mainly Enriched In The Golgi
Colocalizes With Nherf1/Ebp50 In Membrane Ruffles
Alternative Antibody Names Anti-H(+/Cl(- Exchange Transporter 3 antibody
Anti-Chloride Channel Protein 3 antibody
Anti-Clc-3 antibody
Anti-Chloride Transporter Clc-3 antibody
Anti-CLCN3 antibody

Information sourced from Uniprot.org

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