| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-H+/Cl-exchange transporter 3 (597-647 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN3 |
| Gene ID: |
1182 |
| Uniprot ID: |
CLCN3_HUMAN |
| Immunogen Region: |
597-647 aa |
| Specificity: |
This antibody detects endogenous levels of CLCN3 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human CLCN3 at the amino acid range 597-647 |
| Post Translational Modifications | N-glycosylated. |
| Function | Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. |
| Protein Name | H(+/Cl(- Exchange Transporter 3Chloride Channel Protein 3Clc-3Chloride Transporter Clc-3 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneCell MembraneIsoform 1 Is Localized Mainly In Late EndosomesIsoform 2: Golgi Apparatus MembraneCell ProjectionRuffle MembraneIsoform 2 Is Mainly Enriched In The GolgiColocalizes With Nherf1/Ebp50 In Membrane Ruffles |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 3 antibodyAnti-Chloride Channel Protein 3 antibodyAnti-Clc-3 antibodyAnti-Chloride Transporter Clc-3 antibodyAnti-CLCN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
