Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-CLCN3 antibody (597-647 aa) (STJ195735)

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STJ195735
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-H+/Cl-exchange transporter 3 (597-647 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLCN3
Gene ID: 1182
Uniprot ID: CLCN3_HUMAN
Immunogen Region: 597-647 aa
Specificity: This antibody detects endogenous levels of CLCN3 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human CLCN3 at the amino acid range 597-647
Post Translational Modifications N-glycosylated.
Function Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
Protein Name H(+/Cl(- Exchange Transporter 3
Chloride Channel Protein 3
Clc-3
Chloride Transporter Clc-3
Database Links Reactome: R-HSA-2672351
Cellular Localisation Isoform 1: Early Endosome Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Lysosome Membrane
Cell Membrane
Isoform 1 Is Localized Mainly In Late Endosomes
Isoform 2: Golgi Apparatus Membrane
Cell Projection
Ruffle Membrane
Isoform 2 Is Mainly Enriched In The Golgi
Colocalizes With Nherf1/Ebp50 In Membrane Ruffles
Alternative Antibody Names Anti-H(+/Cl(- Exchange Transporter 3 antibody
Anti-Chloride Channel Protein 3 antibody
Anti-Clc-3 antibody
Anti-Chloride Transporter Clc-3 antibody
Anti-CLCN3 antibody

Information sourced from Uniprot.org

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