| Tissue Specificity | Predominantly expressed in skeletal muscles. |
| Function | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization. Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide. |
| Protein Name | Chloride Channel Protein 1Clc-1Chloride Channel Protein - Skeletal Muscle |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaT-Tubule |
| Alternative Antibody Names | Anti-Chloride Channel Protein 1 antibodyAnti-Clc-1 antibodyAnti-Chloride Channel Protein - Skeletal Muscle antibodyAnti-CLCN1 antibodyAnti-CLC1 antibody |
Information sourced from Uniprot.org
