| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCA1 (22-150) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCA1 |
| Gene ID: |
1179 |
| Uniprot ID: |
CLCA1_HUMAN |
| Immunogen Region: |
22-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human CLCA1 (NP_001276.2). |
| Immunogen Sequence: |
NSLIQLNNNGYEGIVVAIDP NVPEDETLIQQIKDMVTQAS LYLFEATGKRFYFKNVAILI PETWKTKADYVRPKLETYKN ADVLVAESTPPGNDEPYTEQ MGNCGEKGERIHLTPDFIAG KKLAEYGPQ |
| Tissue Specificity | Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. |
| Post Translational Modifications | Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. |
| Function | May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 1Calcium-Activated Chloride Channel Family Member 1Hclca1Calcium-Activated Chloride Channel Protein 1Cacc-1Hcacc-1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular SideProtein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 1 antibodyAnti-Calcium-Activated Chloride Channel Family Member 1 antibodyAnti-Hclca1 antibodyAnti-Calcium-Activated Chloride Channel Protein 1 antibodyAnti-Cacc-1 antibodyAnti-Hcacc-1 antibodyAnti-CLCA1 antibodyAnti-CACC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
