| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium-activated chloride channel regulator 1 (192-242) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCA1 |
| Gene ID: |
1179 |
| Uniprot ID: |
CLCA1_HUMAN |
| Immunogen Region: |
192-242 |
| Specificity: |
This antibody detects endogenous levels of human CLCA1 |
| Immunogen: |
Synthesized peptide derived from human CLCA1 AA range: 192-242 |
| Post Translational Modifications | Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. |
| Function | May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 1Calcium-Activated Chloride Channel Family Member 1Hclca1Calcium-Activated Chloride Channel Protein 1Cacc-1Hcacc-1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular SideProtein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 1 antibodyAnti-Calcium-Activated Chloride Channel Family Member 1 antibodyAnti-Hclca1 antibodyAnti-Calcium-Activated Chloride Channel Protein 1 antibodyAnti-Cacc-1 antibodyAnti-Hcacc-1 antibodyAnti-CLCA1 antibodyAnti-CACC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
