Anti-Claudin 7 antibody [10E7-10B7-8G3] (STJA0033484)

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STJA0033484
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Claudin 7 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 10E7-10B7-8G3
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Chromatography
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:500
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: CLDN7
Gene ID: 1366
Uniprot ID: CLD7_HUMAN
Immunogen: Synthesized peptide derived from human Claudin 7
Tissue Specificity Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Post Translational Modifications Phosphorylated.
Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Protein Name Claudin-7
Cldn-7
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Cell Junction
Tight Junction
Co-Localizes With Epcam At The Basolateral Cell Membrane And Tight Junction
Alternative Antibody Names Anti-Claudin-7 antibody
Anti-Cldn-7 antibody
Anti-CLDN7 antibody
Anti-CEPTRL2 antibody
Anti-CPETRL2 antibody

Information sourced from Uniprot.org

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