| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIRBP (1-172) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:100IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIRBP |
| Gene ID: |
1153 |
| Uniprot ID: |
CIRBP_HUMAN |
| Immunogen Region: |
1-172 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CIRBP (NP_001271.1). |
| Immunogen Sequence: |
MASDEGKLFVGGLSFDTNEQ SLEQVFSKYGQISEVVVVKD RETQRSRGFGFVTFENIDDA KDAMMAMNGKSVDGRQIRVD QAGKSSDNRSRGYRGGSAGG RGFFRGGRGRGRGFSRGGGD RGYGGNRFESRSGGYGGSRD YYSSRSQSGGYSDRSSGGSY RDSYDSYATHNE |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. |
| Protein Name | Cold-Inducible Rna-Binding ProteinA18 HnrnpGlycine-Rich Rna-Binding Protein Cirp |
| Cellular Localisation | NucleusNucleoplasmCytoplasmTranslocates From The Nucleus To The Cytoplasm After Exposure To Uv RadiationTranslocates From The Nucleus To The Cytoplasm Into Stress Granules Upon Various Cytoplasmic StressesSuch As Osmotic And Heat ShocksIts Recruitment Into Stress Granules Occurs In The Absence Of Tiar Proteins |
| Alternative Antibody Names | Anti-Cold-Inducible Rna-Binding Protein antibodyAnti-A18 Hnrnp antibodyAnti-Glycine-Rich Rna-Binding Protein Cirp antibodyAnti-CIRBP antibodyAnti-A18HNRNP antibodyAnti-CIRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
