| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIR1 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIR1 |
| Gene ID: |
9541 |
| Uniprot ID: |
CIR1_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CIR1 (NP_004873.3). |
| Immunogen Sequence: |
MGKSFANFMCKKDFHPASKS NIKKVWMAEQKISYDKKKQE ELMQQYLKEQESYDNRLLMG DERVKNGLNFMYEAPPGAKK ENKEKEETEGETEYKFEWQK GAPREKYAKDDMNIRDQPFG IQVRNVRCIKCHKWGHVNTD RECPLFGLSGINASSVPTDG |
| Tissue Specificity | Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. |
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. |
| Protein Name | Corepressor Interacting With Rbpj 1Cbf1-Interacting CorepressorRecepin |
| Cellular Localisation | Nucleus SpeckleCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Corepressor Interacting With Rbpj 1 antibodyAnti-Cbf1-Interacting Corepressor antibodyAnti-Recepin antibodyAnti-CIR1 antibodyAnti-CIR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TXLNA knockout (KO) HeLa cells, using [KO Validated] TXLNA Rabbit polyclonal antibody (STJ11100765) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89702/358186/STJ11100765_1__45157.1713122500.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TXLNA knockout (KO) HeLa cells, using [KO Validated] TXLNA Rabbit polyclonal antibody (STJ11100765) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
