| Function | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a 4Fe-4S cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. |
| Protein Name | AnamorsinCytokine-Induced Apoptosis Inhibitor 1Fe-S Cluster Assembly Protein Dre2 Homolog |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Anamorsin antibodyAnti-Cytokine-Induced Apoptosis Inhibitor 1 antibodyAnti-Fe-S Cluster Assembly Protein Dre2 Homolog antibodyAnti-CIAPIN1 antibodyAnti-CUA001 antibodyAnti-PRO0915 antibody |
Information sourced from Uniprot.org
