Anti-CIAO1 antibody (1-339aa) [AT6C9] (STJA0041657)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human CIAO1 (1-339aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-CIAO1 (1-339aa) for use in ELISA and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT6C9 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIAO1 |
| Gene ID | 9391 |
| Uniprot ID | CIAO1_HUMAN |
| Accession Number | NP_004795 |
| Immunogen | Recombinant human CIAO1 (1-339aa) purified from E. coli |
| Immunogen Region | 1-339aa |
Additional Info
| Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
| Protein Name | Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1Wd Repeat-Containing Protein 39 |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1 antibodyAnti-Wd Repeat-Containing Protein 39 antibodyAnti-CIAO1 antibodyAnti-CIA1 antibodyAnti-WDR39 antibody |
Information sourced from Uniprot.org