Immunofluorescence analysis of C6 cells using CHTF18 Rabbit polyclonal antibody (STJ119791) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-CHTF18 antibody (794-975) (STJ119791)

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STJ119791
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHTF18
Gene ID: 63922
Uniprot ID: CTF18_HUMAN
Immunogen Region: 794-975
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).
Immunogen Sequence: GTMLAYSLTYRQERTPDGQY IYRLEPNVEELCRFPELPAR KPLTYQTKQLIAREIEVEKM RRAEASARVENSPQVDGSPP GLEGLLGGIGEKGVHRPAPR NHEQRLEHIMRRAAREEQPE KDFFGRVVVRSTAVPSAGDT APEQDSVERRMGTAVGRSEV WFRFNEGVSNAVRRSLYIRD LL
Function Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.
Protein Name Chromosome Transmission Fidelity Protein 18 Homolog
Hctf18
Chl12
Database Links Reactome: R-HSA-174411
Cellular Localisation Nucleus
Associates With Chromatin During S Phase
Alternative Antibody Names Anti-Chromosome Transmission Fidelity Protein 18 Homolog antibody
Anti-Hctf18 antibody
Anti-Chl12 antibody
Anti-CHTF18 antibody
Anti-C16orf41 antibody
Anti-CTF18 antibody

Information sourced from Uniprot.org

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