| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHTF18 |
| Gene ID: |
63922 |
| Uniprot ID: |
CTF18_HUMAN |
| Immunogen Region: |
794-975 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1). |
| Immunogen Sequence: |
GTMLAYSLTYRQERTPDGQY IYRLEPNVEELCRFPELPAR KPLTYQTKQLIAREIEVEKM RRAEASARVENSPQVDGSPP GLEGLLGGIGEKGVHRPAPR NHEQRLEHIMRRAAREEQPE KDFFGRVVVRSTAVPSAGDT APEQDSVERRMGTAVGRSEV WFRFNEGVSNAVRRSLYIRD LL |
| Function | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage. |
| Protein Name | Chromosome Transmission Fidelity Protein 18 HomologHctf18Chl12 |
| Database Links | Reactome: R-HSA-174411 |
| Cellular Localisation | NucleusAssociates With Chromatin During S Phase |
| Alternative Antibody Names | Anti-Chromosome Transmission Fidelity Protein 18 Homolog antibodyAnti-Hctf18 antibodyAnti-Chl12 antibodyAnti-CHTF18 antibodyAnti-C16orf41 antibodyAnti-CTF18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
