| Tissue Specificity | Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-9Nicotinic Acetylcholine Receptor Subunit Alpha-9Nachr Alpha-9 |
| Database Links | Reactome: R-HSA-629594Reactome: R-HSA-9667769 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-9 antibodyAnti-Nicotinic Acetylcholine Receptor Subunit Alpha-9 antibodyAnti-Nachr Alpha-9 antibodyAnti-CHRNA9 antibodyAnti-NACHRA9 antibody |
Information sourced from Uniprot.org
