Anti-CHRNA9 antibody (50-100 aa) (STJ97703)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human CHRNA9 at the amino acid range 50-100
General Information
| Short Description | Rabbit polyclonal anti-Neuronal acetylcholine receptor subunit alpha-9 (50-100 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHRNA9 |
| Gene ID | 55584 |
| Uniprot ID | ACHA9_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human CHRNA9 at the amino acid range 50-100 |
| Immunogen Region | 50-100 aa |
| Specificity | AChR Alpha 9 Polyclonal Antibody detects endogenous levels of cholinergic receptor, nicotinic, alpha 9 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes. nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-9Nicotinic Acetylcholine Receptor Subunit Alpha-9Nachr Alpha-9 |
| Database Links | Reactome: R-HSA-629594Reactome: R-HSA-9667769 |
| Cellular Localisation | Synaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-9 antibodyAnti-Nicotinic Acetylcholine Receptor Subunit Alpha-9 antibodyAnti-Nachr Alpha-9 antibodyAnti-CHRNA9 antibodyAnti-NACHRA9 antibody |
Information sourced from Uniprot.org