![Anti-CHRM2 nanobody [SAA1214] (STJN000120)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200733/412915/STJN000120-SDS-PAGE-1__30740.1749232451.jpg?c=1 "Anti-CHRM2 nanobody [SAA1214] (STJN000120)")
![Anti-CHRM2 nanobody [SAA1214] (STJN000120)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200733/412915/STJN000120-SDS-PAGE-1__30740.1749232451.jpg?c=1 "Anti-CHRM2 nanobody [SAA1214] (STJN000120)")
Anti-CHRM2 nanobody [SAA1214] (STJN000120)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Muscarinic Acetylcholine Receptor M2 is suitable for use in Flow Cytometry and RIA research applications. |
| Applications | FC/RIA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1214 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | CHRM2 |
| Gene ID | 1129 |
| Uniprot ID | ACM2_HUMAN |
Additional Info
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol. |
| Protein Name | Muscarinic Acetylcholine Receptor M2 |
| Database Links | Reactome: R-HSA-390648Reactome: R-HSA-418594Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePhosphorylation In Response To Agonist Binding Promotes Receptor Internalization |
| Alternative Nanobody Names | Anti-Muscarinic Acetylcholine Receptor M2 nanobodyAnti-CHRM2 nanobody |
Information sourced from Uniprot.org