Function | Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization. Isoform 2: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. |
Protein Name | Chondroitin Sulfate Synthase 2Chondroitin Glucuronyltransferase 2Chondroitin-Polymerizing FactorChpfGlucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase IiN-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase IiN-Acetylgalactosaminyltransferase 2 |
Database Links | Reactome: R-HSA-2022870 |
Cellular Localisation | Isoform 1: Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmCytosolIsoform 3: CytoplasmMitochondrionIsoform 2: Mitochondrion Matrix |
Alternative Antibody Names | Anti-Chondroitin Sulfate Synthase 2 antibodyAnti-Chondroitin Glucuronyltransferase 2 antibodyAnti-Chondroitin-Polymerizing Factor antibodyAnti-Chpf antibodyAnti-Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase Ii antibodyAnti-N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase Ii antibodyAnti-N-Acetylgalactosaminyltransferase 2 antibodyAnti-CHPF antibodyAnti-CSS2 antibodyAnti-UNQ651 antibodyAnti-PRO1281 antibody |
Information sourced from Uniprot.org