| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
| Protein Name | Calcineurin B Homologous Protein 2Hepatocellular Carcinoma-Associated Antigen 520 |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly Localized In A Juxtanuclear RegionColocalizes With Slc9a3 In The Juxtanuclear Region And At The Plasma MembraneExported From The Nucleus To The Cytoplasm Through A Nuclear Export Signal (Nes) PathwayMay Shuttle Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcineurin B Homologous Protein 2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 520 antibodyAnti-CHP2 antibodyAnti-HCA520 antibody |
Information sourced from Uniprot.org
