Anti-CHMP1B antibody (STJA0007154)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CHMP1B
General Information
| Short Description | Rabbit polyclonal anti-Charged multivesicular body protein 1b for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHMP1B |
| Gene ID | 57132 |
| Uniprot ID | CHM1B_HUMAN |
| Immunogen | Synthesized peptide derived from human CHMP1B |
| Specificity | This antibody detects endogenous levels of CHMP1B at Human |
Additional Info
| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. |
| Protein Name | Charged Multivesicular Body Protein 1bChmp1.5Chromatin-Modifying Protein 1bChmp1bVacuolar Protein Sorting-Associated Protein 46-2Vps46-2Hvps46-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolEndosomeLate Endosome MembranePeripheral Membrane ProteinLocalizes To The Midbody Of Dividing CellsColocalizing With Cep55 And Chmp5Localized At The Periphery Of The Fleming Body |
| Alternative Antibody Names | Anti-Charged Multivesicular Body Protein 1b antibodyAnti-Chmp1.5 antibodyAnti-Chromatin-Modifying Protein 1b antibodyAnti-Chmp1b antibodyAnti-Vacuolar Protein Sorting-Associated Protein 46-2 antibodyAnti-Vps46-2 antibodyAnti-Hvps46-2 antibodyAnti-CHMP1B antibodyAnti-C18orf2 antibody |
Information sourced from Uniprot.org