| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. |
| Protein Name | Charged Multivesicular Body Protein 1aChromatin-Modifying Protein 1aChmp1aVacuolar Protein Sorting-Associated Protein 46-1Vps46-1Hvps46-1 |
| Database Links | Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinNucleus MatrixThe Cytoplasmic Form Is Partially Membrane-Associated And Localizes To Early EndosomesThe Nuclear Form Remains Associated With The Chromosome Scaffold During MitosisOn OverexpressionIt Localizes To Nuclear Bodies Characterized By Nuclease-Resistant Condensed Chromatin |
| Alternative Antibody Names | Anti-Charged Multivesicular Body Protein 1a antibodyAnti-Chromatin-Modifying Protein 1a antibodyAnti-Chmp1a antibodyAnti-Vacuolar Protein Sorting-Associated Protein 46-1 antibodyAnti-Vps46-1 antibodyAnti-Hvps46-1 antibodyAnti-CHMP1A antibodyAnti-CHMP1 antibodyAnti-KIAA0047 antibodyAnti-PCOLN3 antibodyAnti-PRSM1 antibody |
Information sourced from Uniprot.org
