Western blot analysis of extracts of 293T cells, using (STJ11105752) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-CHM antibody (1-100) [S5752RM] (STJ11105752)

SKU:
STJ11105752
£129.50 - £574.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S5752RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:100-1:500
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHM
Gene ID: 1121
Uniprot ID: RAE1_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386).
Immunogen Sequence: MADTLPSEFDVIVIGTGLPE SIIAAACSRSGRRVLHVDSR SYYGGNWASFSFSGLLSWLK EYQENSDIVSDSPVWQDQIL ENEEAIALSRKDKTIQHVEV
Function Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Protein Name Rab Proteins Geranylgeranyltransferase Component A 1
Choroideremia Protein
Rab Escort Protein 1
Rep-1
Tcd Protein
Database Links Reactome: R-HSA-6803205
Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibody
Anti-Choroideremia Protein antibody
Anti-Rab Escort Protein 1 antibody
Anti-Rep-1 antibody
Anti-Tcd Protein antibody
Anti-CHM antibody
Anti-REP1 antibody
Anti-TCD antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ140112 Anti-CHM antibody (1-80aa N-Term) (STJ140112) Goat Polyclonal Human/Rat/Mouse/Monkey/Canine WB
STJ110643 Anti-CHM antibody (120-210) (STJ110643) Rabbit Polyclonal Human WB/ELISA
STJ140142 Anti-CHM antibody (617 to C-Term) (STJ140142) Goat Polyclonal Human/Rat/Mouse/Monkey/Canine WB
STJ11103302 Anti-NKX6-1 antibody (1-100) (STJ11103302) Rabbit Polyclonal Human/Mouse/Rat WB/IHC-P/ELISA
STJ11103949 Anti-FOXD1 antibody (1-100) (STJ11103949) Rabbit Polyclonal Human/Mouse/Rat WB/ELISA
STJ11103817 Anti-SLC35A1 antibody (1-100) (STJ11103817) Rabbit Polyclonal Human/Mouse WB/ELISA
STJ11103820 Anti-GPX5 antibody (1-100) (STJ11103820) Rabbit Polyclonal Mouse WB/ELISA
STJ115955 Anti-LMX1B antibody (1-100) (STJ115955) Rabbit Polyclonal Human/Mouse/Rat WB/ELISA
!