| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Chicken |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen Region: | 21-315 |
| Specificity: | Recombinant Protein corresponding to a sequence within amino acids 21-315 of Chicken IL12B (NP_998736.1). |
| Immunogen Sequence: | QWKLRENVYVIESEWNDETP AKKVKLTCDTSDEALPVYWK KGTELKGTGKTLTTEVKEFP DAGNYTCLSAKTHEIISYSF FLITKVDSNGQMIRSILKSY KEPSKTFLKCEAKNYSGIFT CSWMTENESPSVKFTIRSLK GSQGDVTCSSPVARTDKSVT EYTAQCQKENYCPFAEEHQP TEMFLEVIDEVEYENYTSSF FIRDIIKPDPPQCQYASTNG TVTWTYPKTWSTPKSYFPL |
| Background | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
Information sourced from Uniprot.org