| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHIA (1-368) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHIA |
| Gene ID: |
27159 |
| Uniprot ID: |
CHIA_HUMAN |
| Immunogen Region: |
1-368 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CHIA (NP_001244932.1). |
| Immunogen Sequence: |
MVSTPENRQTFITSVIKFLR QYEFDGLDFDWEYPGSRGSP PQDKHLFTVLVQEMREAFEQ EAKQINKPRLMVTAAVAAGI SNIQSGYEIPQLSQYLDYIH VMTYDLHGSWEGYTGENSPL YKYPTDTGSNAYLNVDYVMN YWKDNGAPAEKLIVGFPTYG HNFILSNPSNTGIGAPTSGA GPAGPYAKESGIWAYYEICT FLKNGATQGWDAPQEVPYAY QGNVWVGYDNIKSFDIKAQ |
| Tissue Specificity | Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. |
| Function | Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. |
| Protein Name | Acidic Mammalian ChitinaseAmcaseLung-Specific Protein Tsa1902 |
| Database Links | Reactome: R-HSA-189085 |
| Cellular Localisation | Isoform 1: SecretedSecretion Depends On Egfr ActivityIsoform 2: CytoplasmIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Acidic Mammalian Chitinase antibodyAnti-Amcase antibodyAnti-Lung-Specific Protein Tsa1902 antibodyAnti-CHIA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
