Anti-CHI3L1 antibody [SAA1632] (STJA0020060)

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STJA0020060
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Chitinase-3-Like Protein 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1632
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: CHI3L1
Gene ID: 1116
Uniprot ID: CH3L1_HUMAN
Post Translational Modifications Glycosylated.
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name Chitinase-3-Like Protein 1
39 Kda Synovial Protein
Cartilage Glycoprotein 39
Cgp-39
Gp-39
Hcgp-39
Ykl-40
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Perinuclear Region
Endoplasmic Reticulum
Alternative Antibody Names Anti-Chitinase-3-Like Protein 1 antibody
Anti-39 Kda Synovial Protein antibody
Anti-Cartilage Glycoprotein 39 antibody
Anti-Cgp-39 antibody
Anti-Gp-39 antibody
Anti-Hcgp-39 antibody
Anti-Ykl-40 antibody
Anti-CHI3L1 antibody

Information sourced from Uniprot.org