| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5141RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:5000-1:24000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHD4 |
| Gene ID: |
1108 |
| Uniprot ID: |
CHD4_HUMAN |
| Immunogen Region: |
1520-1700 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1700 of human CHD4. (NP_001264.2). |
| Immunogen Sequence: |
ELAEVEENKKMSQPGSPSPK TPTPSTPGDTQPNTPAPVPP AEDGIKIEENSLKEEESIEG EKEVKSTAPETAIECTQAPA PASEDEKVVVEPPEGEEKVE KAEVKERTEEPMETEPKGAA DVEKVEEKSAIDLTPIVVED KEEKKEEEEKKEVMLQNGET PKDLNDEKQKKNIKQRFMFN I |
| Tissue Specificity | Widely expressed. |
| Function | ATP-dependent helicase that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 4Chd-4Atp-Dependent Helicase Chd4Mi-2 Autoantigen 218 Kda ProteinMi2-Beta |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9031628Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociates With Centrosomes In InterphaseLocalizes To Sites Of Dna Damage In A Manner Dependent On Zmynd8 And Znf687 |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 4 antibodyAnti-Chd-4 antibodyAnti-Atp-Dependent Helicase Chd4 antibodyAnti-Mi-2 Autoantigen 218 Kda Protein antibodyAnti-Mi2-Beta antibodyAnti-CHD4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
