Anti-CHD1L antibody [R01-3W3] (STJA0036851)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CHD1L
General Information
| Short Description | Rabbit monoclonal anti-CHD1L for use in WB, IHC-P, ICC, IF, IP and FC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3W3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:40FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CHD1L |
| Gene ID | 9557 |
| Uniprot ID | CHD1L_HUMAN |
| Immunogen | A synthesized peptide derived from human CHD1L |
Additional Info
| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. |
| Function | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1-LikeAmplified In Liver Cancer Protein 1 |
| Database Links | Reactome: R-HSA-5696395Reactome: R-HSA-5696400 |
| Cellular Localisation | NucleusChromosomeLocalizes At Sites Of Dna DamageRecruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2 |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibodyAnti-Amplified In Liver Cancer Protein 1 antibodyAnti-CHD1L antibodyAnti-ALC1 antibody |
Information sourced from Uniprot.org