| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CFHR1 |
| Gene ID: | 3078 |
| Uniprot ID: | FHR1_HUMAN |
| Immunogen Region: | 151-330 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-330 of human CFHR1 (NP_002104.2). |
| Immunogen Sequence: | PTVQNAHILSRQMSKYPSGE RVRYECRSPYEMFGDEEVMC LNGNWTEPPQCKDSTGKCGP PPPIDNGDITSFPLSVYAPA SSVEYQCQNLYQLEGNKRIT CRNGQWSEPPKCLHPCVISR EIMENYNIALRWTAKQKLYL RTGESAEFVCKRGYRLSSRS HTLRTTCWDGKLEYPTCAKR |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Post Translational Modifications | N-glycosylated. Two forms are observed.one with a single side chain and the other with two. |
| Function | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. |
| Protein Name | Complement Factor H-Related Protein 1Fhr-1H Factor-Like Protein 1Fhl-1H-Factor-Like 1H36 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Factor H-Related Protein 1 antibodyAnti-Fhr-1 antibodyAnti-H Factor-Like Protein 1 antibodyAnti-Fhl-1 antibodyAnti-H-Factor-Like 1 antibodyAnti-H36 antibodyAnti-CFHR1 antibodyAnti-CFHL antibodyAnti-CFHL1 antibodyAnti-CFHL1P antibodyAnti-CFHR1P antibodyAnti-FHR1 antibodyAnti-HFL1 antibodyAnti-HFL2 antibody |
Information sourced from Uniprot.org