| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CFB |
| Gene ID: | 629 |
| Uniprot ID: | CFAB_HUMAN |
| Immunogen Region: | 26-259 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-259 of Complement factor B (CFB) (NP_001701.2). |
| Immunogen Sequence: | TPWSLARPQGSCSLEGVEIK GGSFRLLQEGQALEYVCPSG FYPYPVQTRTCRSTGSWSTL KTQDQKTVRKAECRAIHCPR PHDFENGEYWPRSPYYNVSD EISFHCYDGYTLRGSANRTC QVNGRWSGQTAICDNGAGYC SNPGIPIGTRKVGSQYRLED SVTYHCSRGLTLRGSQRRTC QEGGSWSGTEPSCQDSFMYD TPQEVAEAFLSSLTETIEGV DAEDGHGPGEQQKR |
| Function | Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. |
| Protein Name | Complement Factor BC3/C5 ConvertaseGlycine-Rich Beta GlycoproteinGbgPbf2Properdin Factor B Cleaved Into - Complement Factor B Ba Fragment - Complement Factor B Bb Fragment |
| Database Links | Reactome: R-HSA-173736Reactome: R-HSA-174577Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Factor B antibodyAnti-C3/C5 Convertase antibodyAnti-Glycine-Rich Beta Glycoprotein antibodyAnti-Gbg antibodyAnti-Pbf2 antibodyAnti-Properdin Factor B Cleaved Into - Complement Factor B Ba Fragment - Complement Factor B Bb Fragment antibodyAnti-CFB antibodyAnti-BF antibodyAnti-BFD antibody |
Information sourced from Uniprot.org