| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CES3 |
| Gene ID: | 23491 |
| Uniprot ID: | EST3_HUMAN |
| Immunogen Region: | 269-568 |
| Immunogen Sequence: | WPLAQKIANTLACSSSSPAE MVQCLQQKEGEELVLSKKLK NTIYPLTVDGTVFPKSPKEL LKEKPFHSVPFLMGVNNHEF SWLIPRGWGLLDTMEQMSRE DMLAISTPVLTSLDVPPEMM PTVIDEYLGSNSDAQAKCQA FQEFMGDVFINVPTVSFSRY LRDSGSPVFFYEFQHRPSSF AKIKPAWVKADHGAEGAFVF GGPFLMDESSRLEATEEEKQ LSLTMMAQWTHFARTGDPN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1). |
| Tissue Specificity | Expressed in liver, colon and small intestine. |
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-4-(1-piperidino)-1-piperidino-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
| Protein Name | Carboxylesterase 3Liver Carboxylesterase 31 Homolog |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Carboxylesterase 3 antibodyAnti-Liver Carboxylesterase 31 Homolog antibodyAnti-CES3 antibodyAnti-UNQ869 antibodyAnti-PRO1887 antibody |
Information sourced from Uniprot.org
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