| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA.C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity. |
| Protein Name | Ceramide Synthase 6Cers6Lag1 Longevity Assurance Homolog 6Sphingoid Base N-Palmitoyltransferase Cers6 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 6 antibodyAnti-Cers6 antibodyAnti-Lag1 Longevity Assurance Homolog 6 antibodyAnti-Sphingoid Base N-Palmitoyltransferase Cers6 antibodyAnti-CERS6 antibodyAnti-LASS6 antibody |
Information sourced from Uniprot.org
