Anti-CEP78 antibody (301-350 aa) (STJ92231)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CEP78 at the amino acid range 301-350
General Information
| Short Description | Rabbit polyclonal anti-Centrosomal protein of 78 kDa (301-350 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CEP78 |
| Gene ID | 84131 |
| Uniprot ID | CEP78_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CEP78 at the amino acid range 301-350 |
| Immunogen Region | 301-350 aa |
| Specificity | CEP78 Polyclonal Antibody detects endogenous levels of CEP78 protein. |
Additional Info
| Function | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16. |
| Protein Name | Centrosomal Protein Of 78 KdaCep78 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyMainly Localizes At The Centriolar WallBut Also Found In The Pericentriolar MaterialExpressed In Photoreceptor Inner Segment |
| Alternative Antibody Names | Anti-Centrosomal Protein Of 78 Kda antibodyAnti-Cep78 antibodyAnti-CEP78 antibodyAnti-C9orf81 antibody |
Information sourced from Uniprot.org