| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CEP350 |
| Gene ID: |
9857 |
| Uniprot ID: |
CE350_HUMAN |
| Immunogen Region: |
1-300 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CEP350 (NP_055625.4). |
| Immunogen Sequence: |
MRSSKSKEVPLPNPRNSQSK DTVQADITTSWDALSQTKAA LRHIENKLEVAPTSTAVCDS VMDTKKSSTSATRKISRKDG RYLDDSWVNAPISKSTKSRK EKSRSPLRATTLESNVKKNN RVEFREPLVSYREIHGAPSN FSSSHLESKHVYCVDVNEEK TESGNWMIGSREERNIRSCD FESSQSSVINDTVVRFLNDR PAIDALQNSECLIRMGASMR TEEEMPNRTKGSENNLKLS |
| Tissue Specificity | Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. |
| Protein Name | Centrosome-Associated Protein 350Cep350Centrosome-Associated Protein Of 350 Kda |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleNucleusCentrioleCilium Basal BodyAssociated With Mitotic SpindlesNuclearIn Discrete FociAssociated With Intermediate FilamentsAlso Present In The Pericentrosomal AreaLocalizes On Both Mother And Daughter CentriolesLocalizes To An Axial Position On The Mother CentrioleLocalizes To The Distal End Of The Centriole On The Subdistal Appendage Region |
| Alternative Antibody Names | Anti-Centrosome-Associated Protein 350 antibodyAnti-Cep350 antibodyAnti-Centrosome-Associated Protein Of 350 Kda antibodyAnti-CEP350 antibodyAnti-CAP350 antibodyAnti-KIAA0480 antibodyAnti-GM133 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
